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Heat-Treated Lactobacillus plantarum

Allerpac's Heat-Treated Lactobacillus plantarum (HK-L137) is an IMMUNOBIOTIC that is established in Japan and developed by Japanese scientists.

Allerpac's HK-L137 is a heat-treated strain of Lactobacillus plantarum (L137), a lactic acid bacteria commonly found in a wide variety of fermented foods. As a live organism, Lactobacillus plantarum (L137) is considered a beneficial probiotic, but its immune-supporting benefits are inhibited by its structure and lack of stability within digestive fluid.

Allerpac's Heat-Treated Lactobacillus plantarum (HK-L137) is heat treated at a precise moment during the growth phase to break down the cell membrane and components, eliminating the inhibitors and stabilizing the product for survival in the gastric fluids. This allows for a powerful stimulating effect on the production of  IL-12, an important factor in immune system function.

Research shows that Allerpac's Heat-treated Lactobacillus plantarum (HK-L137) is active within the small intestine, where it passes through the intestinal lumen to stimulate production of IL-12, in turn, produces T cells and activates the effector cells such as NK cells and CTLs. IFN-β is one of the most important cytokines directly involved in immune defense.

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The safety of lactobacilli are well-documented in general. Lactobacillus plantarum is considered as having a history of safe use in food. The safety of Heat-Treated Lactobacillus plantarum (HK-L137)  was confirmed both in toxicity studies and in clinical trials, and no potential problems were observed.

Allerpac's Heat-Treated Lactobacillus plantarum (HK-L137) is Generally Recognised As Safe (GRAS) in the United States.


Allerpac's Heat-Treated Lactobacillus plantarum (HK-L137) shows high immune-enhancing activity such as anti-allergic effects, anti-cancer effects, anti-viral effects.

It enhances the body's natural defenses to protect against  a wide range of pathogenic microbes, tumor cells, viruses, allergen, etc.

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